Indena

Meriva®的新功效领域 - Indena的姜黄素

Phytosome®:临床证据表明这是自然而安全的

帮助身体排毒

Curcuma Longa L.(Zingiberaceae生姜家族的成员)是东南亚的多年生草药植物,在中国,印度,印度尼西亚和泰国广泛种植。它的标志性黄色来自三种化学上不同的化合物,这些化合物是植物的活性成分:姜黄素,单毒性毒性和双甲氧西氧化毒素。在市场上和科学文献中,所有这些姜黄素通常被共同称为姜黄素。但是,每个姜黄素具有不同的化学性质和颜色,并且共同或单独地工作,它们的应用领域与健康的身体对炎症的反应有关。此外,姜黄素是世界上研究最多的植物提取物之一,因为已经对其进行了大约100项人类研究,涉及数千名受试者。自年以来,Indena开发了Meriva®,其姜黄提取物由Phytosome®配制,Phytosome®是公司的签名产品之一。Meriva®的功效通过了35多个人类的科学研究证明,其中至少三分之一是通过随机对照方案进行的,特别是与心血管,肠道和眼部健康,体育中的营养,关节健康中的营养,健康的血液水平和支持性护理。在这些涉及2000多人受试者的研究中,从未报道过不良反应。这就是为什么Meriva®CurcuminPhytosome®被认为是现实生活中的Guardian™。Meriva®的优势之一是使用Phytosome®配方。 As known, like many botanical ingredients also turmeric has poor solubility in water and is difficult to absorb by the intestine, with consequent limitation of its bioavailability. To face and overcome this problem, Indena has developed since years Phytosome®, a delivery system which optimizes the bioavailability and pharmacokinetic profile of active compounds of natural origin using 100% food grade ingredients (lecithin). Lecithins are natural surfactants which, together with bile salts, participate in the physiological process of absorption of lipophilic compounds and constitute the lipid double layer of cell membranes, making compounds, not readily soluble in water, more easily absorbable for example by the intestine. Despite its long history, Indena’s Meriva® Curcumin Phytosome® continues to reveal new areas of efficacy for human wellbeing. New clinical evidence shows that Meriva® is indeed an effective oxidative stress modulator, also in the support of kidney detoxing and filtering functions. Such evidence comes from studies which have been done by important Italian universities, specifically to evaluate the effectiveness of curcumin Phytosome® for kidney health support. Chronic renal disease is an inflammatory based disorder, and curcumin properties in modulating body response through its antioxidant properties are well known and scientifically proven. The mentioned studies showed significant effectiveness of Meriva® Curcumin Phytosome® in being a natural and safe help for kidney health support. The first, new study, by the University of Milan[1], focused on chronic kidney disease (CKD) subjects. Chronic kidney disease (CKD) is a condition due to the progressive loss of renal function and widely recognized as one of the most relevant risk factors for developing cardiovascular diseases (CVDs). In the pilot study, 24 CKD subjects and 20 healthy volunteers were recruited. CKD subjects followed nutritional counselling and were supplemented with Meriva® for six months. The parameters evaluated at baseline and after 3–6 months were uremic toxins, metagenomic of gut microbiota (which, as known, can play a pivotal role in controlling the origin of systemic inflammatory state and CKD progression) and nutritional, inflammatory, and oxidative status.

姜黄素显着升级血浆炎性介质和脂质过氧化。关于肠道菌群,补充姜黄素6个月后,观察到肠道微生物种群的平衡组成更加平衡。同样,由于在补充组中未观察到长期补充后Meriva®的安全性。这项最近的研究扩展了Chieti-Pescara大学[2]先前探索的使用条件的“保持肾脏健康”,其目的是评估Meriva®在临时肾脏功能障碍(TKD)和氧化增加的受试者中的补充。压力水平。在Chieti-Pescara大学举行的研究中,受试者遵循标准管理或标准管理以及补充Meriva®的补充,并根据大藻(AER> 24小时的AER> 300 mg白蛋白)或Microalbuminuria(AER 30 - 300毫克/天)进行了分裂蛋白尿),成为TKD的标志。临床证据表明,与对照组相比,由于其抗氧化特性而与对照组相比,蛋白尿症在所有受试者中均降低,在补充剂组中具有统计学意义的积极作用(p <0.05)。所有TKD受试者的氧化应激水平均高:4周后,在补充组中受到显着影响(p <0.05)。大多数补充受试者在4周时都没有疲劳,这是TKD影响的另一个方面。 As for safety, compliance and tolerability to Meriva® were good. Indena’s Meriva® is the most studied curcumin on the market, in over 10 different health conditions including renal aging. Its formulation as a standardized turmeric extract containing the full bouquet of curcuminoids, not just curcumin, based on Indena’s Phytosome®, makes such ingredient actually unique.

参考:

1. Pivari,F。;Mingione,A。;Piazzini,G。;Ceccarani,c。Ottaviano,E。;Brasacchio,c。Dei Cas,M。;Vischi,M。;Cozzolino,M.G。;Fogagnolo,P。; et al.. Nutrients 2022, 14, 231. https://doi.org/10.3390/ nu14010231

2. Gianni Belcaro等人,Panminerva Medica 2019年12月; 61(4):444-8

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